Laboratory Medicine Program

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Dr. Mahmoud Khalifa

Pathology at the Laboratory Medicine Program is among Canada’s largest and most experienced group of pathologists. In addition to over 50,000 surgical pathology specimens and 25,000 cytology specimens performed within our affiliated hospitals, the team responds to over 6,000 referrals annually from hospitals across Ontario dependent on our expertise for pathological diagnosis in support of clinical management.

The staff's commitment to research, teaching and clinical services keeps them at the forefront of oncology, transplant, cardiovascular and neuroscience diagnostics. Our pathologists have access to many integrated techniques, including advanced cytology, automated histology, immunohistochemistry, flow cytometry, electron microscopy, cancer cytogenetics, and molecular diagnostics. These resources enable our team to provide opinions that meet the level of sophistication required by our clients. The pathology division is also home to the largest histocompatibility laboratory (HLA) in Canada and provides testing in support of transplant programs at the Hospital for Sick Children, St. Michael’s Hospital, Toronto General Hospital and Princess Margaret Hospital.

Services range from consultations that provide diagnostic advice on complex cases, to routine interpretation of tests, collaborative diagnosis, and technical services. Our areas of expertise include breast pathology, cardiovascular pathology, cytopathology, dermatopathology, endocrine pathology, gastrointestinal and hepatic pathology, genitourinary pathology, gynecologic pathology, head and neck pathology, hematopathology, neuropathology, pulmonary pathology and renal pathology.

Tests and consultation:

Cytopathology

• Liquid Based Cervical Cancer Screening and HPV Testing
• Fine Needle Aspiration with Morphologic, Proteomic and Genomic Tumour Analyses

Immunopathology

• Immunohistochemistry for Routine and Esoteric Markers
• Immunofluorescence, specializing in renal and skin studies

Electron Microscopy

• Routine and specialized services, offering digitized images

Histocompatibility Lab

• HLA-B27 assays
• HLA studies for solid organ and bone marrow transplants
• Cytotoxic studies

Cancer Cytogenetics

• Classical cytogenetics
• Fluorescence in Situ Hybridization (FISH), including HER2neu

Molecular Diagnostics

• Full Oncology services, including k-ras 
• DNA and RNA Analysis Including Southern Blot, PCR/RT-PCR, and Quantitative PCR
• Tissue Identification Analysis

Research

• Animal and human tissue studies

 

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