• Patients & Visitors
• Clinics & Services
• Focus of Care
• Krembil Neurosciences
• Medical & Community Care
• Musculoskeletal Health & Arthritis
• Multi-Organ Transplant
• Peter Munk Cardiac Centre
• PMH Cancer Program
• Surgical & Critical Care
• Toronto Rehab
• Find a Doctor
• Research
• Technology Transfer
• Education
• Careers at UHN
• Health Professionals
• Media
• For Staff

Milestones/Innovations

• Discovered that language processing may be reorganized in the brain, in patients with left temporal lobe epilepsy. (2001)

Current Research

Basic science research includes investigations into:

• Epigenetic factors
• Normal and abnormal brain oscillations
• Electronic coupling via gap junctions
• Ion channel distribution
• Identification of newly expressed genes in experimental seizure models
• Evaluating the therapeutic basis of the ketogenic diet in patients with intractable seizures
Evaluating the role of ovarian sex steroid hormones in the modulation and control of seizures

Clinical science research includes investigations into:

• Patterns of memory impairments
• Vagus nerve and deep brain stimulation for seizure control
• Patterns of neural activation in memory and language
Trials of new antiepileptic medications giving the program early access to the newest pharmacological therapies
• fMRI and spectroscopy for localization of cerebral function in seizure patients
• Study of the scope and burden of depression in patients with epilepsy
• Use of the mathematical "chaos" analysis approach for seizure prediction

For more information on research at the Krembil Neuroscience Centre, visit the Toronto Western Research Institute.