Research

Atherosclerosis: Understanding the Beginnings of Disease
The development of lesions that thicken artery walls due to the build-up of cells and fatty materials, such as cholesterol, is known as atherosclerosis. While the exact mechanisms behind how atherosclerotic lesions form are currently unknown, important study findings from a team of investigators at TGRI may ultimately change this.....more

Cardiology: Learning the Benefits of Salt
A TGRI team led by Dr. Vivek Rao and colleagues has identified a novel pretreatment strategy in an animal model that can improve the movement of blood and preserves cardiac blood vessel function following transplantation. These findings could potentially lead to improved early and late survival after cardiac transplantation.

The team pretreated donor hearts with a hypertonic saline solution (HTS)—a simple salt solution—immediately before transplantation and then maintained the organs in cooler conditions for approximately six hours before transplantation. Findings show that in comparison to hearts that were not treated with HTS, HTS-pretreated donor hearts had limited injury to cells lining the interior surface of blood vessels and enhanced recovery in ventricles after transplantation.

Stroke: Protein Suppression Prevents Brain Cell Death
After cardiac arrest, the brain is deprived of oxygen, which causes brain cells to die typically within a few days. Findings published from the lab of TWRI’s Dr. Michael Tymianski are helping investigators prevent the death of brain cells......more

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