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Krembil Neuroscience Centre
The Swallowing Centre
 

Patient Population
The Swallowing Centre, established in 1988, was designed to provide a multi-disiplinary approach to the assessment, diagnosis, and management of persons with swallowing disorders, with a major academic research component.

The Centre involves the disciplines of speech-language pathology, gastroenterology, and nutrition, but also requires constant collaboration within other professional disciplines such as otolaryngology, neurology, respirology and radiology.

In 1998, Speech Language Pathology serviced 1,344 consultations, with 87 per cent involving a significant swallowing component. Following initial clinical assessment, approximately 25 per cent require the use of a special videofluoroscopic swallow study which is conducted jointly by a speech-language pathologist and radiologist. To date, the speech-language pathologists at TWH have conducted more than 3,700 procedures in their evaluation and management of swallowing-disordered patients.

In addition to the inpatient program, the Swallowing Centre has developed an ambulatory Swallowing Clinic which is dedicated to the evaluation, treatment and study of a variety of swallowing disorders. About 24 patients are seen in the Swallowing Clinic per month by Speech-Language Pathology, an increase of 142% since 1996.

Education
Members of the swallowing team are active in education of medical and allied health professionals in their own and other disciplines.

Research
Program research has both clinical and basic components and is directed to both the esophageal and oropharyngeal stages of swallowing.

Research projects include:

  1. electrical and mechanical activity to differentiate between esophageal and gastric components;
  2. localization of esophageal afferent and efferent neurons;
  3. brainstem electrical recording to establish central mechanisms for control of esophageal peristalsis;
  4. assessment of esophageal tone;
  5. regional and myogenic differences smooth muscle esophagus with particular attention to oscillator properties, ion channels, SNARE proteins and constitutive nitric oxide synthesis;
  6. investigation and treatment of adverse effects associated with administration of extracellular hemoglobin (supported by Hemosol Inc);
  7. assessment of the esophageal interstitial cells of Cajal by morphology and tracing techniques
  8. MRI assessment of swallowing in normals and stroke patients effect of pharyngeal stimulation on recovery of dysphagia in stroke patients establishing a data base of incidence and course of dysphagia in stroke patients
  9. computer programs for analysis and modeling of gut electrical activity
 
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